Pitzer-Labor für Arthroseforschung
Prof. Dr. Max LöhningPitzer-Labor für Arthroseforschung
Prof. Dr. Max Löhning
CV - Akademischer Werdegang und Schlüsselpublikationen (nur auf Englisch verfügbar)
Scientific Career
- Since 2015 University Professor (W3, permanent) and Head of Pitzer Laboratory of Osteoarthritis Research at Charité – Universitätsmedizin Berlin and DRFZ Berlin
- 2013 – 2014 Offer of W3 Professorship position and Head of Department of Immunology at Universitätsmedizin Greifswald; 2014 declined
- 2012 – 2015 University Professor (W2, permanent) of Experimental Immunology, Charité, Berlin
- 2006 – 2011 Lichtenberg Professor (W1) at Charité, funded by Volkswagen Foundation
- 2002 – 2006 Postdoctoral fellow with R.M. Zinkernagel and H. Hengartner at the Institute of Experimental Immunology, ETH and University Hospital Zurich, Switzerland, funded by Ernst Schering Foundation
- 2000 – 2002 Postdoctoral fellow with A. Radbruch at DRFZ Berlin
- 1999 – 2000 Research fellow with W.E. Paul at NIH, NIAID, Bethesda, MD, and with K.M. Murphy at Washington University-School of Medicine, St. Louis, MO, USA
Education
- 1996 – 2000 PhD thesis as fellow of German National Academic Foundation at the Institute of Genetics, University of Cologne; 2000 Dr. rer. nat. (“very good, with distinction”)
- 1990 – 1996 Biology studies as fellow of German National Academic Foundation (Studienstiftung des deutschen Volkes) at the University of Mainz; 1996 Diploma (“with distinction”)
Boards
- Since 2023 Chair of the Foundation Council of Schering Foundation
- Since 2020 Member of the Board of Trustees of Hermann and Elise née Heckmann Wentzel Foundation
- Since 2017 Board member and Council member of Berlin-Brandenburg Academy of Sciences
- Since 2017 Spokesperson of the class Biological Sciences and Medicine of Berlin-Brandenburg Academy of Sciences (BBAW); 2014–2017 Vice-Spokesperson
- Since 2017 Board member of Deutsche Rheumastiftung of German Society for Rheumatology (DGRh)
- Since 2014 Founder and Board member of BIH Young Science at Berlin Institute of Health (BIH)
- 2013 – 2016 Head of the Integrated Research Training Group (iRTG, GRK) of Collaborative Research Center 650 (SFB 650) at Charité, Berlin
- Since 2012 Vice-Director of Research Center ImmunoSciences at Charité; 2006 Board member
- Since 2009 Board member of ZIBI Graduate School at Humboldt-Universität zu Berlin
- 2009 – 2016 Board member and Scientific Secretary (2009–2011) of SFB 650 at Charité
- Since 2007 Board member of the International Max Planck Research School for Infectious Diseases and Immunology (IMPRS-IDI), Berlin
Awards
- Since 2020 Guest Professor at Goethe-Universität Frankfurt/Main, Medical Faculty
- Since 2013 Member of Berlin-Brandenburg Academy of Sciences (BBAW)
- 2010 Georges-Köhler-Prize of the German Society for Immunology (DGfI)
- 2006 – 2015 Lichtenberg Professorship of Experimental Immunology at Charité funded by Volkswagen Foundation
- 2004 – 2009 Member of Die Junge Akademie (The German Young Academy) at the BBAW and the German National Academy of Sciences Leopoldina
- 2004 Robert-Koch-Postdoctoral-Prize of Robert Koch Foundation
- 2002 – 2004 Postdoctoral fellowship of Ernst Schering Foundation
- 2000 Avrion-Mitchison-Prize for Rheumatology of Ernst Schering Foundation
- 2000 Otto-Westphal-PhD-Prize of the German Society for Immunology
- 1993 – 2000 Diploma and PhD fellowships of the German National Academic Foundation
Third Party Funding
Selection from 2012 – ongoing
- 2022-2026 Dr. Rolf M. Schwiete Foundation, grant 2021-035, Molecular Switch for Biological Joint Regeneration in Osteoarthritis.
- 2021-2024 Willy Robert Pitzer Foundation, grant 21-033, Pitzer Laboratory of Osteoarthritis Research.
- 2021-2024 German Federal Ministry of Education and Research (BMBF), project 01KC2011C, PROOF-DESFERAL.
- 2021-2024 German Research Foundation (DFG), LO 1542/5-1: Purinergic Alarmin Signaling in Acute and Chronic Viral Infection.
- 2019 – 2021 German Research Foundation (DFG), LO 1542/4-1: Dissection of cell-cell communication networks in chronic viral infection by kinetic immune-cell monitoring and mathematical modeling.
- 2016 – 2018 Swiss National Science Foundation (SNF), Sinergia grant CRSII3_160772: The alarmin interleukin-33 in infection, immunity and autoimmunity.
- 2015 – 2020 Willy Robert Pitzer Foundation, Pitzer Laboratory of Osteoarthritis Research.
- 2006 – 2015 Volkswagen Foundation, Lichtenberg Professorship of Experimental Immunology.
- 2013 – 2017 EU, FP7, Marie Curie Initial Training Network (ITN), Quantitative T Cell Immunology (QuanTI), TP 6: Cytokine memory in T cells.
- 2013 – 2016 DFG, SFB 650, Head of iRTG Suppression of unwanted immune responses.
- 2013 – 2016 DFG, SFB 650, TP 28: Suppression of autoreactive T cell responses by Th2 cells.
- 2013 – 2016 DFG, LO 1542/3-1: Transcriptional programming and re-programming of pro-inflam-matory T helper 1 cells.
- 2013 – 2015 BMBF, e:Bio – T-Sys, project WP 3 TP 5: Interplay of epigenetic and transcriptional imprinting of T helper cell fate.
- 2012 – 2014 DFG, Epigenetic signatures of memory T cells and their functional relevance. Joint project with A. Hamann, Charité Berlin.
Key Publications
- Hegazy, A.N., C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T.M. Brunner, M. Peine, A. Fröhlich, N. Ishaque, R.M. Marek, J. Zhu, T. Höfer & M. Löhning. Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities. Science Advances 2024, 10:eadk2693. doi: 10.1126/sciadv.adk2693.
- Brunner*, T.M., S. Serve*, A.F. Marx, J. Fadejeva, P. Saikali, M. Dzamukova, N. Durán-Hernández, C. Kommer, F. Heinrich, P. Durek, G.A. Heinz, T. Höfer, M.F. Mashreghi, R. Kühn, D.D. Pinschewer & M. Löhning. A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T cell responses. Nature Immunology 2024, 25:256-267. doi:10.1038/s41590-023-01697-6. )*Shared first authors. [Paper of the Month of Charité Faculty Board, March 2024]
- Shen, P., S. Serve, P. Wu, X. Liu, Y. Dai, N. Durán-Hernández, D.T.M. Nguyen, M. Fuchs, T. Maleitzke, M.J. Reisener, M. Dzamukova, K. Nussbaumer, T.M. Brunner, Y. Li, V. Holecska, G.A. Heinz, F. Heinrich, P. Durek, G. Katsoula, C. Gwinner, T. Jung, E. Zeggini, T. Winkler, M.F. Mashreghi, M. Pumberger, C. Perka & M. Löhning. NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis. Proceedings of the National Academy of Sciences USA 2023, 120:e2207993120. doi: 10.1073/pnas.2207993120.
- Marx*, A.F., S.M. Kallert*, T.M. Brunner*, J.A. Villegas, F. Geier, J. Fixemer, T. Abreu-Mota, P. Reuther, W.V. Bonilla, J. Fadejeva, M. Kreutzfeldt, I. Wagner, P. Aparicio-Domingo, L. Scarpellino, M. Charmoy, D.T. Utzschneider, C. Hagedorn, M. Lu, K. Cornille, K. Stauffer, F. Kreppel, D. Merkler, D. Zehn, W. Held, S.A. Luther, M. Löhning# & D.D. Pinschewer#. The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection. Immunity 2023, 56:813-828. doi: 10.1016/j.immuni.2023.01.029. )*Shared first authors, #Shared senior authors.
- Dzamukova, M., T. Brunner, J. Miotla-Zarebska, F. Heinrich, L. Brylka, M.F. Mashreghi, A. Kusumbe, R. Kühn, T. Schinke, T. Vincent & M. Löhning. Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth. Nature Communications 2022, 13:3059. doi: 10.1038/s41467-022-30618-8.[Avrion-Mitchison-Prize for Rheumatology to Maria Dzamukova, Dec. 2022].
- Shen, P., P. Wu, T. Maleitzke, M.J. Reisener, G.A. Heinz, F. Heinrich, P. Durek, C. Gwinner, T. Winkler, M. Pumberger, C. Perka, M.F. Mashreghi & M. Löhning. Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome. Frontiers in Bioengineering and Biotechnology 2022, 10:1046127. doi: 10.3389/fbioe.2022.1046127.
- Li, Y., H. Gao, T.M. Brunner, X. Hu, Y. Yan, Y. Liu, L. Qiao, P. Wu, M. Li, Q. Liu, F. Yang, J. Lin, M. Löhning# & P. Shen#. Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice. Stem Cell Research & Therapy 2022, 13:155. doi: 10.1186/s13287-022-02838-8. )#Shared senior authors.
- Muñoz, M., A.N. Hegazy, T.M. Brunner, V. Holecska, R.M. Marek, A. Fröhlich & M. Löhning. Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10. Proceedings of the National Academy of Sciences USA 2021, 118:e2002787118. doi: 10.1073/pnas.2002787118.
- Peine, M., R.M. Marek & M. Löhning. IL-33 in T cell differentiation, function, and immune homeostasis. Trends in Immunology 2016, 37:321-333. doi: 10.1016/j.it.2016.03.007.
- Helmstetter, C., M. Flossdorf, M. Peine, A. Kupz, J. Zhu, A.N. Hegazy, M.A. Duque-Correa, Q. Zhang, Y. Vainshtein, A. Radbruch, S.H. Kaufmann, W.E. Paul, T. Höfer & M. Löhning. Individual T helper cells have a quantitative cytokine memory. Immunity 2015, 42:108-122. doi: 10.1016/j.immuni.2014.12.018, Immunity cover image
- Baumann, C., W.V. Bonilla, A. Fröhlich, C. Helmstetter, M. Peine, A.N. Hegazy, D.D. Pinschewer & M. Löhning. T-bet– and Stat4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses. Proceedings of the National Academy of Sciences USA 2015, 112:4056-4061. doi: 10.1073/pnas.1418549112.
- Bhattacharya, A., A.N. Hegazy, N. Deigendesch, L. Kosack, J. Cupovic, R.K. Kandasamy, A. Hildebrandt, D. Merkler, A.A. Kühl, B. Vilagos, C. Schliehe, I. Panse, K. Khamina, H. Baazim, I. Arnold, L. Flatz, H.C. Xu, P.A. Lang, A. Aderem, A. Takaoka, G. Superti-Furga, J. Colinge, B. Ludewig, M. Löhning# & A. Bergthaler#. Superoxide dismutase 1 protects hepatocytes from type I interferon-driven oxidative damage. Immunity 2015, 43:974-986. doi: 10.1016/j.immuni.2015.10.013. )#Shared senior authors.
- Peine, M., S. Rausch, C. Helmstetter, A. Fröhlich, A.N. Hegazy, A.A. Kühl, C.G. Grevelding, T. Höfer, S. Hartmann & M. Löhning. Stable T‑bet+GATA-3+ Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biology 2013, 11:e1001633. doi: 10.1371/journal.pbio.1001633.
- Bonilla, W.V., A. Fröhlich, K. Senn, S. Kallert, M. Fernandez, S. Johnson, M. Kreutzfeldt, A.N. Hegazy, C. Schrick, P.G. Fallon, R. Klemenz, S. Nakae, H. Adler, D. Merkler, M. Löhning# & D.D. Pinschewer#. The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 2012, 335:984-989. doi: 10.1126/science.1215418. )#Shared senior authors.
- Hegazy, A.N., M. Peine, C. Helmstetter, I. Panse, A. Fröhlich, A. Bergthaler, L. Flatz, D.D. Pinschewer, A. Radbruch & M. Löhning. Interferons direct Th2 cell reprogramming to generate a stable GATA-3+T-bet+ cell subset with combined Th2 and Th1 cell functions. Immunity 2010, 32:116-128. doi: 10.1016/j.immuni.2009.12.004. [Immunity cover image].
AG Löhning
Pitzer-Labor Arthroseforschung: Molekulare Schalter zur biologischen Gelenkregeneration