Forschungskoordination

Scientific career

Since 01.01.2017 Scientific coordinator for the Schwiete-Laboratory for Microbiota and Inflammation
Since 1.01.2016 Scientific coordinator at DRFZ

1.05.2007-31.12.2015 Scientist at Charité Universitätsmedizin Berlin Medical Clinic for Rheumatology and DRFZ (AG Prof. Dr. Alf Hamann)
1.12.2009-31.12.2013 Research officer of the Research Center ImmunoSciences at the Charité (RCIS)
1.01.2004-31.03.2006 Scientist at Charité Universitätsmedizin Berlin Medical Clinic for Gastroenterology (AG PD Dr. B. M. Wittig)

Education

Promotion:

1.10. 2000-31.12.2003 Doctoral thesis at Charité Universitätsmedizin Berlin Medical Clinic for Rheumatology and DRFZ (AG Prof. Dr. Alf Hamann) “magna cum laude”

Studies:

1.06.2000 Diploma in Biochemistry at Free University Berlin

1.10.1999 – 31.05.2000 Diploma thesis at Institut für Molecular Biology und Biochemistry at Free University Berlin (Prof. Dr. W. Reutter) „sehr gut“

Memberships

German Society for Immunology (DGfI)

Publications

Pfeil J, Simonetti M, Lauer U, Volkmer R, von Thülen B, Durek P, Krähmer R, Leenders F, Hamann A, Hoffmann U. Tolerogenic Immunomodulation by PEGylated Antigenic Peptides. Front Immunol. 2020 Oct 9;11:529035. doi: 10.3389/fimmu.2020.529035. PMID: 33162973; PMCID: PMC7581722.

Gupta S, Pfeil J, Kumar S, Poulsen C, Lauer U, Hamann A, Hoffmann U*, Haag R*. Tolerogenic modulation of the immune response by oligoglycerol- and polyglycerol-peptide conjugates. Bioconjug Chem. 2015 Apr 15;26(4):669-79. (*contributed equally)

Hoffmann U, Pink M, Lauer U, Heimesaat MM, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U. “Regulation and migratory role of P-selectin ligands during intestinal inflammation”. PLoS One. 2013 Apr 22;8(4):e62055.

Ute Hoffmann, Claudia Hayford, Andreas Stallmach, Ulrich Wahnschaffe, Martin Zeitz, Ursula Günthert, Bianca Maria Wittig
“CD44v7 ligation induces cell death and prevents macrophage maturation in patients with Crohn’s disease” Cell Death Differ. 2007 Aug;14(8):1542-51

Ute Kretschmer, Kerstin Bonhagen, Gudrun F. Debes, Uta Syrbe, Hans-Willi Mittrücker, Klaus J. Erb, Oliver Liesenfeld, Dietmar Zaiss Thomas Kamradt, Alf Hamann
“Expression of selectin ligands on murine effector- and IL-10 producing CD4+ T cells from non-infected and infected tissues” Eur J Immunol. 2004 Nov;34(11):3070-81.

Coautorships

Bhatia S, Lauster D, Bardua M, Ludwig K, Angioletti-Uberti S, Popp N, Hoffmann U, Paulus F, Budt M, Stadtmüller M, Wolff T, Hamann A, Böttcher C, Herrmann A, Haag R. Linear polysialoside outperforms dendritic analogs for inhibition of influenza virus infection in vitro and in vivo. Biomaterials. 2017 Sep;138:22-34. doi: 10.1016/j.biomaterials.2017.05.028.

Lauster D, Glanz M, Bardua M, Ludwig K, Hellmund M, Hoffmann U, Hamann A, Böttcher C, Haag R, Hackenberger CPR, Herrmann A. Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition. Angew Chem Int Ed Engl. 2017 May 15;56(21):5931-5936. doi: 10.1002/anie.201702005.

Elisabeth E. Kenngott, Jennifer Pfeil, Ute Hoffmann, Uta Lauer, Anja A. Kühl, Anne Rigby, Anton Pernthaner and Alf Hamann. Facilitated Peptide Transport via the Mucosal Epithelium: Impact on Tolerance Induction. Front. Immunol., 06 March 2017 https://doi.org/10.3389/fimmu.2017.00216

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M. Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2015 Aug 26.

Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2014 Dec 8.

Francesca Diane M. Liu, Elisabeth E. Kenngott, Micha F. Schroter, Anja Kuehl, Silke Jennrich, Ralf Watzlawick, Ute Hoffmann, Thorsten Wolff, Stephen Norley, Alexander Scheffold, Jason S. Stumhofer, Christiaan J. M. Saris, Jan M. Schwab, Christopher A. Hunter, Gudrun F. Debes ,Alf Hamann. „Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza” PLoS Pathog. 2014 May 8;10(5):e1004110.