Stellvertretender Wissenschaftlicher Direktor, Leiter Programmbereich 3, Systemrheumatologie

• Since 2022 Deputy Scientific Director DRFZ
• Since 2022 Head Programme Area Systems Rheumatology
• Since 2020 Scientific Head “BCRT/DRFZ Single-Cell Laboratory for Advanced Cellular Therapies”
• Since 2016 Group Leader “Therapeutic Gene Regulation”, Programme Area III: Regenerative Rheumatology at the DRFZ Berlin and
• Scientific Head “Regine von Ramin Laboratory for Molecular Rheumatology, Next Generation Sequencing”
• 2007 – 2016 Research Associate at department: Cell Biology (Head: Prof. Dr. Andreas Radbruch) at the DRFZ, Berlin

• 2003 – 2007 PhD thesis at the Charité Universitätsmedizin Berlin, Berlin, Institute of Medical Immunology, Supervisors, Prof. Dr. H.-D. Volk / Prof. Dr. P.-M. Kloetzel; “Functional analysis of the transcription factor STAT3 regulated by the induction of the cytoprotective enzyme heme oxygenase-1”.
• 2002 – 2003 Diploma thesis at the Charité Universitätsmedizin Berlin, Institute of Medical Immunology, Supervisor, Prof. Dr. H.-D. Volk; “Strategies for the diagnosis of subclinical and clinical acute rejection episodes in renal transplantation”
• 1998 – 2003 University study at the Free University of Berlin, Berlin (Germany) Department of Biology, Pharmacy und Chemistry, Field: Biochemistry diploma, subjects: Biochemistry, Biophysics, Immunology, Biology, Organic Chemistry, Physical Chemistry and Physics.

Boards

• Study Group Coordinator of EFIS-IL-Study Group “Non-coding RNA and epigenetic regulation in immune cells”

Memberships

• Deutsche Gesellschaft für Immunologie (DGFI)

• 2011 Wolfgang Schulze Award 2011, „Therapeutic use of microRNAs in rheumatology“.

Selection from 2011 – ongoing

• 2017 – 2021 EFRE 1.8/11 „Aufbau eines Applikationslabors zur Identifikation von Genschaltern, die chronische Entzündungen steuern“. European Regional Development Fund. PI: Mir-Farzin Mashreghi.
• 2013 – 2016 SFB650 (DFG), “Cellular approaches to a suppression of unwanted immune reactions”; Project TP 23, “Targeting of pathogenic T helper cells in chronic rheumatic inflammation”. PIs: Andreas Radbruch, Mir-Farzin Mashreghi and Hyun-Dong Chang,
• 2013 – 2015 e:Bio (BMBF), T-Sys, Systems biology of T helper cells, immunomodulation – not just immunosuppression. WP2, “MicroRNAs and genes regulating the transition of protective into pathogenic memory T helper cells in chronic inflammatory diseases”. PI of TP3: Mir-Farzin Mashreghi.
• 2008 – 2011 FORSYS, Systems analysis of regulatory networks in T-helper cells: Mathematical modelling of transcriptional T-cell activation and differentiation. WP2, “MicroRNA profiles in T-cell differentiation and their functional memory”. PI of TP4: Mir-Farzin Mashreghi.

1. Witkowski, C.Tizian, M. Ferreira-Gomes, D. Niemeyer, T. C. Jones, F. Heinrich, S. Frischbutter, S. Angermair, T. Hohnstein, I. Mattiola, P. Nawrath, S. Mc Ewen, S. Zocche, E. Viviano, G. A. Heinz, M. Maurer, U. Kölsch, R. L. Chua, T. Aschman, C. Meisel, J. Radke15, B. Sawitzki, J. Roehmel, K. Allers, V.Moos, T.Schneider, L. Hanitsch, M. A. Mall, C. Conrad, H. Radbruch, C.U. Duerr, J. A. Trapan, E. Marcenaro, T. Kallinich, V. M. Corman, F. Kurth, L. E. Sander, C. Drosten, S. Treskatsch, P.Durek, A. Kruglov, A. Radbruch, M.F. Mashreghi*, and Andreas Diefenbach*(contributed equaly), Untimely TGFβ 1 responses in severe COVID-19 limit antiviral function of NK cells, Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6.
2. Ferreira-Gomes, M., Kruglov, A., Durek, P., Heinrich, F., Tizian, C., Heinz, G. A., Pascual-Reguant, A., Du, W., Mothes, R., Fan, C., Frischbutter, S., Habenicht, K., Budzinski, L., Ninnemann, J., Jani, P. K., Guerra, G., Lehmann, K., Matz, M., Ostendorf, L., Heiberger, L., Chang, H.-D., Bauherr, S., Maurer, M., Schoenrich, G., Raftery, M., Kallinich, T., Mall, M. A., Angermair, S., Treskatsch, S., Doerner, T., Corman, V. M., Diefenbach, A., Volk, H.-D., Elezkurtaj, S., Winkler, T. H., Dong, J., Hauser, A. E., Radbruch, H., Witkowski, M., Melchers, F., Radbruch, A., Mashreghi, M.-F. SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself Nat Commun 12, 1961 (2021). https://doi.org/10.1038/s41467-021-22210-3
3. Sunkara V, Heinz GA, Heinrich F, Durek P, Mobasheri A, Mashreghi MF*, Lang A*(contributed equally). Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint. Osteoarthritis Cartilage. 2021 Mar 21:S1063-4584(21)00638-5. doi: 10.1016/j.joca.2021.03.007. Epub ahead of print. PMID: 33762205.
4. Maschmeyer P, Heinz GA, Skopnik CM, Lutter L, Mazzoni A, Heinrich F, von Stuckrad SL, Wirth LE, Tran CL, Riedel R, Lehmann K, Sakwa I, Cimaz R, Giudici F, Mall MA, Enghard P, Vastert B, Chang HD, Durek P, Annunziato F, van Wijk F, Radbruch A, Kallinich T, Mashreghi MF. Antigen-driven PD-1+ TOX+ BHLHE40+ and PD-1+ TOX+ EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ. Eur J Immunol. 2020 Dec 9. doi: 10.1002/eji.202048797. Epub ahead of print. PMID: 33296081.
5. R Riedel, R Addo, M Ferreira-Gomes, G Heinz, F Heinrich, J Kummer, V Greiff, D Schulz, C Klaeden, R Cornelis, U Menzel, S Kröger, U Stervbo, R Köhler, C Haftmann, S Kühnel, K Lehmann, P Maschmeyer, MMcGrath, S Naundorf, S Hahne, Ö Sercan-Alp, F Siracusa, J Stefanowski, M Weber, K Westendorf, J Zimmermann, AE Hauser, ST Reddy, P Durek, HD Chang, MF Mashreghi*, A Radbruch*. Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow, Nature communications; *equal contribution  doi: https://doi.org/10.1038/s41467-020-16464-6;
6. Addo RK, Heinrich F, Heinz GA, Schulz D, Sercan-Alp Ö, Lehmann K, Tran CL, Bardua M, Matz M, Löhning M, Hauser AE, Kruglov A, Chang HD, Durek P, Radbruch A, Mashreghi MF. Single-cell transcriptomes of murine bone marrow stromal cells reveal niche-associated heterogeneity. Eur J Immunol. 2019 Sep;49(9):1372-1379. doi: 10.1002/eji.201848053. Epub 2019 Jun 7.
7. Bardua M, Haftmann C, Durek P, Westendorf K, Buttgereit A, Tran CL, McGrath M, Weber M, Lehmann K, Addo RK, Heinz GA, Stittrich AB, Maschmeyer P, Radbruch H, Lohoff M, Chang HD, Radbruch A, Mashreghi MF. MicroRNA-31 Reduces the Motility of Proinflammatory T Helper 1 Lymphocytes. Front Immunol. 2018 Dec 6;9:2813. doi: 10.3389/fimmu.2018.02813. eCollection 2018.
8. Matz M, Heinrich F, Zhang Q, Lorkowski C, Seelow E, Wu K, Lachmann N, Addo RK, Durek P, Mashreghi MF*, Budde K*. The regulation of interferon type I pathway-related genes RSAD2 and ETV7 specifically indicates antibody-mediated rejection after kidney transplantation. The regulation of interferon type I pathway-related genes RSAD2 and ETV7 specifically indicates antibody-mediated rejection after kidney transplantation. Clin Transplant. 2018 Dec;32(12):e13429. doi: 10.1111/ctr.13429. Epub 2018 Nov 18. *equal contribution
9. Matz M, Heinrich F, Lorkowski C, Wu K, Klotsche J, Zhang Q, Lachmann N, Durek P, Budde K, Mashreghi MF. MicroRNA regulation in blood cells of renal transplanted patients with interstitial fibrosis/tubular atrophy and antibody-mediated rejection. PLoS One. 2018 Aug 13;13(8):e0201925. doi: 10.1371/journal.pone.0201925. eCollection 2018.
10. Maschmeyer P, Petkau G, Siracusa F, Zimmermann J, Zügel F, Kühl AA, Lehmann K, Schimmelpfennig S, Weber M, Haftmann C, Riedel R, Bardua M, Heinz GA, Tran CL, Hoyer BF, Hiepe F, Herzog S, Wittmann J, Rajewsky N, Melchers FG, Chang HD, Radbruch A, Mashreghi MF. Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo. J Autoimmun. 2018 May;89:41-52. doi: 10.1016/j.jaut.2017.11.005.
11. Matz M, Fabritius K, Lorkowski C, Dürr M, Gaedeke J, Durek P, Grün JR, Goestemeyer A, Bachmann F, Wu K, Rudolph B, Schmidt D, Weber U, Haftmann C, Unterwalder N, Lachmann N, Radbruch A, Neumayer HH, Mashreghi MF*, Budde K*. Identification of T Cell-Mediated Vascular Rejection After Kidney Transplantation by the Combined Measurement of 5 Specific MicroRNAs in Blood. Transplantation. 2016 Apr;100(4):898-907. *equal contribution
12. Matz M, Lorkowski C, Fabritius K, Durek P, Wu K, Rudolph B, Neumayer HH, Mashreghi MF*, Budde K*. Free microRNA levels in plasma distinguish T-cell mediated rejection from stable graft function after kidney transplantation. Transpl Immunol. 2016 Nov;39:52-59. *equal contribution
13. Haftmann C, Riedel R, Porstner M, Wittmann J, Chang HD, Radbruch A, Mashreghi MF. Direct uptake of Antagomirs and efficient knockdown of miRNA in primary B and T lymphocytes. J Immunol Methods. 2015 Nov;426:128-33.
14. Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015 Apr;45(4):1192-205.
15. Stittrich AB, Haftmann C, Sgouroudis E, Kühl AA, Hegazy AN, Panse I, Riedel R, Flossdorf M, Dong J, Fuhrmann F, Heinz GA, Fang Z, Li N, Bissels U, Hatam F, Jahn A, Hammoud B, Matz M, Schulze FM, Baumgrass R, Bosio A, Mollenkopf HJ, Grün J, Thiel A, Chen W, Höfer T, Loddenkemper C, Löhning M, Chang HD, Rajewsky N, Radbruch A, Mashreghi MF. The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol. 2010 Nov;11(11):1057- 62. doi: 10.1038/ni.1945. Epub 2010 Oct 10.
16. Neumann C, Blume J, Roy U, Teh PP, Vasanthakumar A, Beller A, Liao Y, Heinrich F, Arenzana TL, Hackney JA, Eidenschenk C, Gálvez EJC, Stehle C, Heinz GA, Maschmeyer P, Sidwell T, Hu Y, Amsen D, Romagnani C, Chang HD, Kruglov A, Mashreghi MF, Shi W, Strowig T, Rutz S, Kallies A, Scheffold A. c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis. Nat Immunol. 2019 Apr;20(4):471-481. doi: 10.1038/s41590-019-0316-2. Epub 2019 Feb 18.
17. Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C. Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells. Nat Immunol. 2018 May;19(5):453-463. doi: 10.1038/s41590-018-0082-6. Epub 2018 Apr 9.
18. Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015 Oct 13;6:8576. doi:10.1038/ncomms9576.
19. Weber JP, Fuhrmann F, Feist RK, Lahmann A, Al Baz MS, Gentz LJ, Vu Van D, Mages HW, Haftmann C, Riedel R, Grün JR, Schuh W, Kroczek RA, Radbruch A, Mashreghi MF, Hutloff A. ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med. 2015 Feb 9;212(2):217-33.