Lymphocyte Development
Prof. Dr. Fritz MelchersLymphocyte Development
Prof. Dr. Fritz Melchers
Wissenschaftlicher Werdegang und Publikationen
- Since 2017 Senior Scientist and Group Leader, DRFZ
- 2008 – 2016 Max Planck Fellow
- 2003 – 2007 Senior Research Group Leader, Max Planck Institute for Infection Biology, Berlin
- 1981 – 2001 Director, Basel Institute for Immunology, Basel, Switzerland
- 1970 – 1980 Permanent Member, Basel Institute for Immunology, Basel, Switzerland
- 1970 – 1971 Visiting Scientist, Department of Genetics, Stanford University Medical School
- 1970 Visiting Scientist, Weizmann Institute, Rehovot, Israel
- 1970 Senior Research Assistant, Max Planck Institute for Molecular Genetics, Berlin
- 1968 – 1969 Postdoctoral Fellow, Max Planck Institute for Molecular Genetics, Berlin
- 1965 – 1967 Research Associate, Salk Institute for Biological Studies, La Jolla, CA, USA (Fulbright)
Werdegang
- 1971 Dr. rer. nat. habil., Venia legendi, University of Freiburg i.Br., Faculty of Biology
- 1964 Ph.D. (Dr. rer. nat.), University of Cologne, Germany
- 1961 Dipl. chem., University of Cologne, Germany
2010 – 2018 Tuberculosis Vaccine Initiative, Amsterdam
2003 – 2010 Member and Vice-President, University Council Hannover Medical School, Germany
2002 – 2014 4-Antibody GmbH, Basel, Switzerland, Co-founder
1998 – 2001 President, IUIS (International Union of Immunological Societies)
1996 – 2003 Member “Universitätsrat“, University of Basel, Switzerland
1993 – 1996 Nationaler Forschungsrat der Schweiz, Bern, Switzerland
1992 – 1999 Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany
1986 – 1996 Paul Ehrlich Foundation, Frankfurt am Main, Germany
1986 – 2001 Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Academia Europea
Leopoldina
Norwegian Academy of Science and Letters
Swiss Academy of Medical Sciences
American Academy for Arts and Science
Austrian Academy of Sciences
2018 Leibniz-Chair, Leibniz Association
2017 Cothenius Medal, Leopoldina
2009 M.D.h.c. Medical University Innsbruck, Austria
2007 Novartis Prize for Basic Immunology
2007 M.D.h.c. University of Würzburg, Germany
2006 Ph.D.h.c. University of Leipzig, Germany
2003 M.D.h.c., University of Erlangen- Nuremberg, Germany
2002 Gaikokujin Chomei Kenkyu-shu (Eminent Scientist) Award of the Japanese Society for the Promotion of Science (JSPS) at the University of Tokyo School of Medicine
2002 External Scientific Member, Max Planck-Institute for Infection Biology, Berlin
2002 Emil von Behring Preis, Marburg, Germany
2001 Honorary Professor, Medical Faculty, University of Innsbruck, Austria
2000 San Marino Prize 2000
1997 Max Delbrück Medal, MDC, Berlin, Germany
1996 Robert-Koch Prize, Bonn, Germany
1996 Prausnitz-Medaille, Collegium Internationale Allergologicum (CIA), Vienna
1995 Bundesverdienstkreuz 1. Klasse der Bundesrepublik Deutschland
1994 Ph.D.h.c., Medical College, Thomas Jefferson University, Philadelphia, USA
1990 M.D.h.c., University of Turku, Finland
1988 Commendatore dell Ordine di Sant’ Agata, San Marino
1978 Honorary Professor, Faculty of Biology, Heidelberg University, Germany
1. Kawano Y, Petkau G, Stehle C, Durek P, Heinz GA, Tanimoto K, Karasuyama H, Mashreghi MF, Romagnani C, Melchers F. Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018 May 3;131(18):2026-2035.
2. Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018 Mar 5. doi: 10.1002/eji.201747354.
3. Tornack J, Kawano Y, Garbi N, Hämmerling GJ, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017 Sep;47(9):1477-1487.
4. Wolf I, Bouquet C, Naumann F, Melchers F. Generation of precursor, immature, and mature murine B1-cell lines from c-myc/bcl-xL-overexpressing pre-BI cells. Eur J Immunol. 2017 May;47(5):911-920. doi: 10.1002/eji.201746937. Epub 2017 Apr 6.
5. Tornack J, Reece ST, Bauer WM, Vogelzang A, Bandermann S, Zedler U, Stingl G, Kaufmann SH, Melchers F. Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis. PLoS One. 2017 Jan 3;12(1):e0169119. doi: 10.1371/journal.pone.0169119. eCollection 2017.
6. Wolf I, Bouquet C, Melchers F. cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells. Eur J Immunol. 2016 Nov;46(11):2555-2565.
7. Kawano Y, Petkau G, Wolf I, Tornack J, Melchers F. IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones. Eur J Immunol. 2017 Jan;47(1):206-212. doi: 10.1002/eji.201646677. Epub 2016 Nov 11.
8. Kajikhina K, Melchers F, Tsuneto M. Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver. Sci Rep. 2015 Aug 3;5:12817.
9. Funakoshi S, Shimizu T, Numata O, Ato M, Melchers F, Ohnishi K. BILL-cadherin/cadherin-17 contributes to the survival of memory B cells. PLoS One. 2015 Jan 22;10(1):e0117566. doi: 10.1371/journal.pone.0117566. eCollection 2015.
10.Knoll M, Simmons S, Bouquet C, Grün JR, Melchers F. miR-221 redirects precursor B cells to the BM and regulates their residence. Eur J Immunol. 2013 Sep;43(9):2497-506. doi: 10.1002/eji.201343367. Epub 2013 Jul 8