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Immune Monitoring || Regine von Ramin Lab Molecular Rheumatology
Dr. rer. nat. Andreas Grützkau
 

Immune Monitoring || Regine von Ramin Lab Molecular Rheumatology

Dr. rer. nat. Andreas Grützkau

Deutsches Rheuma-Forschungszentrum Berlin
Cell Biology
Charitéplatz 1
10117 Berlin
Gemany Phone: +49 (0)30 28460-690 Fax: +49 (0)30 28460-603 gruetzkau@drfz.de

CV and Key Publications

Scientific Career
  • Since 2004 Scientific Head of the Regine-von-Ramin-Laboratory for Molecular Rheumatology and the Core Facility for Immune Monitoring at the DRFZ
  • 2001 – 2008 Scientist at the DRFZ (National Genome Research Network)
  • 1995 – 2001 PostDoc at the Dept. of Dermatology, Charité, HU-Berlin
  • 1990 – 1994 PhD student at the Schering AG / Institute of Biochemistry of the Free University of Berlin
Education
  • 1990 – 1994 PhD student at the Schering AG / Institute of Biochemistry of the Free University of Berlin
  • 1983 – 1989 Study of Biochemistry at the Free University Berlin
  • 1978 – 1981 Qualification as Biological Laboratory Technician
Boards and Memberships
  • Associate Editor of “CYTOMETRY Part A”
  • Member of the German Society of Immunology (DGfI)
Third Party Funding (Selection)
  • 2017 – 2022 IMI 2 – JU funded project RTCure, contract no. 777357
  • 2013 – 2019 BMBF „Sysinflame“ (e:med)
  • 2012 – 2016 DFG Collaborative Research Network 650 – Cellular approaches to a suppression of un-wanted immune reactions – from bench to bedside
  • 2012 – 2015 BMBF KMU-innovativ-10: “EPILYZE“ (DNA methylation signatures as innovative biomarkers for the quantitative and qualitative analysis of immune cells)
  • 2011 – 2014 BMBF GERONTOSYS – Verbundprojekt “PRIMAGE” – Protective Immunity in Ageing
  • 2010 – 2014 IMI JU funded project BeTheCure, contract no 115142-2
Key Publications
  1. Shebzukhov Y, Holtze S, Hirseland H, Schäfer H, Radbruch A, Hildebrandt T, Grützkau A. Identification of cross-reactive antibodies for the detection of lymphocytes, myeloid cells and haematopoietic precursors in the naked mole rat. Eur J Immunol. 2019.
  2. Schulz AR, Baumgart S, Schulze J, Urbicht M, Grützkau A, Mei HE. Stabilizing Antibody Cocktails for Mass Cytometry. Cytometry A. 2019 Aug;95(8):910-916. doi: 10.1002/cyto.a.23781. Epub 2019.
  3. Schulte-Wrede U, Sörensen T, Grün JR, Häupl T, Hirseland H, Steinbrich-Zöllner M, Wu P, Radbruch A, Poddubnyy D, Sieper J, Syrbe U, Grützkau A. An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus. Arthritis Res Ther. 2018 Aug 29;20(1):191
  4. Baron U, Werner J, Schildknecht C, Schulze J, Mulu A, Liebert U-G, Sack U, Speckmann C, Gossen M, Wong R, Stevenson D, Babel N, Schürmann D, Baldinger T, Bacchetta R, Grützkau A, Borte S-M and Olek S. Epigenetic Immune Cell Counting in Human Blood Samples: A Novel Platform for Immunodiagnostics and Newborn Screening. Sci Transl Med. 2018 Aug 1;10(452).
  5. Baumgart, S, Peddinghaus, A, Schulte-Wrede, U, Mei, HE & Grützkau, A. OMIP-034: Comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies. Cytometry A. 2017 91, 34-38.
  6. Baumgart S, Schulz AR, Peddinghaus A, Stanislawiak S, Gillert S, Hirseland H, Krauthäuser S, Dose C, Mei HE, Grützkau A. Dual-labelled antibodies for flow and mass cytometry: A new tool for cross-platform comparison and enrichment of target cells for mass cytometry. Eur J Immunol. 2017 Aug;47(8):1377-1385.
  7. Rose T, Grützkau A, Klotsche J, Enghard P, Flechsig A, Keller J, Riemekasten G, Radbruch A, Burmester GR, Dörner T, Hiepe F, Biesen R. Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study. Rheumatology (Oxford). 2017 Sep 1;56(9):1618-1626.
  8. Strauß R, Rose T, Flint SM, Klotsche J, Häupl T, Peck-Radosavljevic M, Yoshida T, Kyogoku C, Flechsig A, Becker AM, Dao KH, Radbruch A, Burmester GR, Lyons PA, Davis LS, Hiepe F, Grützkau A, Biesen R. Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options. J Mol Med (Berl). 2017 Jul;95(7):753-765.
  9. Smiljanovic B, Radzikowska A, Kuca-Warnawin E, Kurowska W, Grün JR, Stuhlmüller B, Bonin M, Schulte-Wrede U, Sörensen T, Kyogoku C, Bruns A, Hermann S, Ohrndorf S, Aupperle K, Backhaus M, Burmester GR, Radbruch A, Grützkau A, Maslinski W, Häupl T. Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint. Ann Rheum Dis. 2018 Feb;77(2):300-308. doi: 10.1136/annrheumdis-2017-211649. Epub 2017 Nov 30.
  10. Stervbo U, Bozzetti C, Baron U, Jürchott K, Meier S, Mälzer JN, Nienen M, Olek S, Rachwalik D, Schulz AR, Neumann A, Babel N, Grützkau A, Thiel A. Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets. Age (Dordr). 2015 Oct;37(5):93.
  11. Stervbo U, Meier S, Mälzer JN, Baron U, Bozzetti C, Jürchott K, Nienen M, Olek S, Rachwalik D, Schulz AR, Waldner JM, Neumann A, Babel N, Grützkau A, Thiel A.Effects of aging on human leukocytes (part I): immunophenotyping of innate immune cells. Age (Dordr). 2015 Oct;37(5):92.
  12. Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. immunoClust: An automated analysis pipeline for the identification of immunophenotypic signatures in high-dimensional cytometric datasets. Cytometry A. 2015 Jul;87(7):603-15.
  13. Kyogoku C, Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Häupl T, Hiepe F, Alexander T, Radbruch A, Grützkau A. Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference? PLoS One. 2013 Dec 31;8(12):e83776.
  14. Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A. The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med (Berl). 2012 Nov;90(11):1295-309.
Immune Monitoring
In search of cell patterns in blood for individualized medicine
Regine von Ramin Lab Molecular Rheumatology
In search of disease-relevant gene regulation patterns
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