Macrophages in chronic inflammation

Prof. Antigoni Triantafyllopoulou, MD

Group Leader, Laboratory Innate Immunity in Rheumatic Diseases
Fachärztin für Rheumatologie und klinische Immunologie

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Charité - Universitätsmedizin Berlin
antigoni.triantafyllopoulou@charite.de

Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)
Ein Institut der Leibniz-Gemeinschaft
Charitéplatz 1
10117 Berlin Phone: +49-30-28460-734 (office)/-675 (lab) Fax: +49-30-28460-603 triantafyllopoulou@drfz.de

CV and Key Publications

Scientific Career

Since 2020 Professor for ‘Innate immunity in Rheumatic Diseases’ (“Angeborene Immunität bei rheumatologischen Erkrankungen”), Charité Berlin
Since 2017 Liaison Group Leader and Rheumatologist, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin and Deutsches Rheuma Forschungszentrum, a Leibnitz Institute, Berlin
2013 – 2017 Junior Group Leader and Rheumatologist, Department of Rheumatology and Clinical Immunology, Freiburg Universitätsklinikum
2009 – 2013 Project Leader, Center of Chronic Immunodeficiency, Freiburg Universitätsklinikum
2005 – 2009 Rheumatology Fellow, Academic-Research Track, Hospital for Special Surgery /Weill Medical College of Cornell University, New York, USA
2002 – 2005 Internal Medicine Resident, Montefiore Medical Center/Albert Einstein College of Medicine, New York, USA
1999 – 2002 Doctoral Student, Department of Pathophysiology, National University of Athens Medical School

Education

2010 Dr., Medicine, National University of Athens Medical School (summa cum laude)
2001 Medical School, National University of Athens, Greece

Awards

2018 ERC Starting Grant ‘Role of the DNA Damage Response in Macrophage Differentiation in Granulomatous Diseases’ (DDR Mac)
2011 – 2014 EU FP7 Marie Curie International Re-integration Grant ‘Regulation of Inflammation by Macrophages in Chronic Granulomatous Diseases’ (RIMinCGD)
2007 – 2010 SLE Lupus Foundation Physician Scientist Fellowship, New York
2005 Outstanding House Officer in Internal Medicine Award, Montefiore Medical Center, New York

Key Publications

Gronke K, Hernández PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019 Feb; 566(7743):249-253.
Viau A, Bienaimé F, Lukas K, Todkar AP, Knoll M, Yakulov TA, Hofherr A, Kretz O, Helmstädter M, Reichardt W, Braeg S, Aschman T, Merkle A, Pfeifer D, Dumit VI,Gubler MC, Nitschke R, Huber TB, Terzi F, Dengjel J, Grahammer F, Köttgen M, Busch H, Boerries M, Walz G, Triantafyllopoulou A, Kuehn EW. Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. EMBO J. 2018
Horn V, Triantafyllopoulou A. DNA damage signaling and polyploid macrophages in chronic in-flammation. Curr Opin Immunol. 2018, 50: 55-63.
Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Vavra M, Schachtrup K, Illert L, Gilleron M, Kirschning C, Triantafyllopoulou A, Henneke P. Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells. EMBO Rep. 2017, e201744121.
Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke M, Wagner D, Dierks C, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher C, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke P, and Triantafyllopoulou A*. DNA damage signaling instructs polyploid macrophage fate in granulomas. Cell. 2016, 167:1264-1280 *Lead contact
Schwab L, Goroncy L, Palaniyandi S, Gautam S, Triantafyllopoulou A, Mocsai A, Reichardt W, Karls-son F.J, Radhakrishnan SV, Hanke K, Schmitt-Graeff A, Freudenberg M, von Loewenich FD, Wolf P, Leonhardt F, Baxan N, Pfeifer D, Schmah O, Schönle A, Martin SF, Mertelsmann R, Duyster J, Finke J, Prinz M, Henneke P, Häcker H, Hildebrandt GC, Häcker G, Zeiser R. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nature Med. 2014, 20: 648-54.
Franzke CW, Cobzaru C, Triantafyllopoulou A, Loeffek S, Horiuchi K, Threadgill DW, Kurz T, van Rooijen N, Bruckner-Tuderman L, Blobel CP. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med. 2012, 209:1105-19.
Kenzel S, Mergen M, von Süßkind-Schwendi J, Wennekamp J, Deshmukh SD, Haeffner M, Triantafyllopoulou A, Fuchs S, Farmand S, Santos-Sierra S, Seufert J, van den Berg TK, Kuijpers TW, Henneke P. Insulin Modulates the Inflammatory Granulocyte Response to Streptococci via Phos-phatidylinositol 3-Kinase. J Immunol. 2012, 189:4582-91.
Triantafyllopoulou A, Franzke C-W, Seshan SV, Perino G, Girardi G, Kalliolias G, Ramanujam M, van Rooijen N, Davidson A, and LB Ivashkiv. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A. 2010, 107:3012-3017.
Kalliolias GD, Zhao B, Triantafyllopoulou A, Park-Min KH, Ivashkiv LB. Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling. Arthritis Rheum. 2010, 62:402-413.
Triantafyllopoulou A, Tapinos N, Moutsopoulos HM. Evidence for coxsackievirus infection in primary Sjogren’s syndrome. Arthritis Rheum. 2004, 50:2897-2902.

Triantafyllopoulou lab

Innate Immunity in Rheumatic Diseases