SFB 1454 – Metaflammation and cellular programming

Metaflammation & Cellular Programming

The long-term goal of this SFB 1454 is to understand what triggers metaflammation and how the associated cellular programming affects organismal physiology and pathology, with a particular focus on sterile inflammatory processes in lifestyle associated non-communicable diseases (NCD).

The research projects concentrate on following topics:

How are cells reprogrammed by defined stimulatory events that are associated with triggers of metaflammation?
How does metabolomic, genomic and epigenetic programming influence the strength, duration and quality of immune responses?
Which mechanisms are operative during metaflammation, and how do they modulate cell-cell interactions and organ-level regulation?
Can we detect, monitor and modulate molecular mechanisms of metaflammation in humans?
How can we best communicate and translate causal relationships observed between modern lifestyle and metaflammation to protect future generations?

The DRFZ is involved in two subprojects: ACLY-mediated macrophage reprogramming in metaflammation and S14 Sphingomyelin induced neuro-immune reprogramming during metaflammation