AER-COMED (sub-project 1): The frequency and effects of combined use of antirheumatic drugs with potential interactions

Subproject 1 will investigate the frequency of concomitant use of methotrexate and metamizole. Methotrexate is a mainstay in the treatment of inflammatory rheumatic diseases, in particular rheumatoid arthritis. Metamizole is often prescribed as an analgesic. The coadministration of metamizole can increase the haematotoxicity of methotrexate, especially in elderly patients. Claims data from the BARMER health insurance will be used for analysis.