- Programme Area 3
Therapeutic Gene Regulation
- Gene regulation
- Next Generation Sequencing
- System immunology
With oligonucleotides against „diseased“ cells
By discovering genes and non-coding RNAs implicated in the pathogenesis of osteoarthritis and other chronic inflammatory diseases, we aim to identify and characterise cells that trigger and drive the pathogenesis of rheumatic diseases. We apply state-of-the-art methods (particularly single-cell-sequencing approaches) to determine which genes and regulatory RNAs are selectively switched on in “disease causing” pathogenic cells versus healthy cells. Genes and regulatory RNAs which keep the pathogenic cells alive would be ideal targets for new therapies. The identification of such types of therapeutic targets will contribute to the development of advanced treatments that lead to remission in patients with rheumatic diseases. Since 2020, our technological expertise has also been applied to studying the pathogenesis of COVID-19.
