ERC Advanced Grant MEM-CLONK – Imprinting and clonality of human NK cell memory

ERC Grants

Immunologist Chiara Romagnani is working on Natural Killer (NK) cells of the innate immune system. She has shown these cells to have similar properties to the classic adaptive memory B and T lymphocytes, as once activated, they also clonally expand and survive for many years therafter. In the project “MEM-CLONK – Imprinting and clonality of human NK cell memory”, she will study the molecular mechanisms driving epigenetic remodeling, clonal selection and maintenance of memory natural killer memory cells. In this way, these cells could be used to specifically target tumor cells.