TRR 167 NeuroMAc – Development, function and potential of myeloid cells in the central nervous system

The main goal of “NeuroMAc  (Development, function and potential of myeloid cells in the central nervous system)” is to better understand the molecular mechanisms of myeloid cell diversity in the CNS and the interactions of microglia with neurons and other glial cells during development, health and perturbation.

The TRR167 aims to define common and distinct genetic pathways for the development of different sets of myeloid cells in the brain, to identify the cellular mechanisms of myeloid cell function during the onset, resolution and recovery of disease in models of neurodegeneration and neuroinflammation and to investigate the therapeutic potential of myeloid cells in preclinical models of CNS diseases.