AER-COMED (sub-project 2): Risks of long-term therapy in young adults with juvenile idiopathic arthritis (JIA)

Despite modern therapies, young people with juvenile idiopathic arthritis (JIA) may still receive long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. This subproject investigates whether these medications are associated with adverse treatment outcomes in young adults (18–25 years) who developed chronic arthritis in childhood or adolescence.
The focus is on the potential risks of long-term use, including gastrointestinal bleeding, high blood pressure, heart attack, stroke, osteoporosis, and thrombosis. The study is based on data from 1,850 individuals included in the JuMBO registry.

Statistical models are used to examine whether there is an association between these adverse events and the prescription of NSAIDs and corticosteroids. The goal is to gain well-founded insights into the safety and potential risks of such long-term therapy.